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Thymosin beta 4 is also one of few compounds in this class with genuine randomised controlled human data, though in a topical ophthalmic formulation rather than a systemic one, RGN-259 eye drops having been evaluated in placebo-controlled Phase 2 and Phase 3 trials (Sosne et al., Cornea 2015 and Int J Mol Sci 2023)
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This finding strongly refutes the simplistic model that depression in IBD is just a psychological reaction
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